Cialis Timeline

The Chronological Development of Cialis

1993: Pharmaceutical co. ICOS started its research on a compound IC351 that inhibits the PDE5 enzyme.

1994: Icos receives its first patent on IC351.

1995: First phase of clinical trials begun.

1997: Icos conducted the first study in patients with erectile dysfunction problem.

1998: Icos and Eli Lilly and Co. form a joint venture to commercialize drugs for the treatment of sexual dysfunction.

1999: Phase III clinical studies begin on IC351.

2001: New drug application is filed with the U.S. Food and Drug Administration for IC351. The company renames the drug Cialis.

April 2002: FDA reviews drug application, saying the company must complete more clinical studies, resolve manufacturing issues and complete labeling.

November 2002: Cialis gets European approval.

February 2003: Marketing of Cialis begins in Europe .

November 2003: US FDA approves Cialis in United States for usage.

December 2003: Cialis is likely to be available for sale from December.

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